Review of Helical Magnetic Structures in Magnetic Microwires

We provide an overview of the helical magnetic structures in magnetic microwires. Having analyzed the experimental data describing the magnetic behavior of magnetic microwires since the 1990s, we found indirect evidence of the existence of various types of helical magnetic structures. Purposeful research has allowed us to discover the spiral magnetic structure as one of the most unusual helical structures. A comparison of the spiral structure with another type of helical structure—elliptical—was carried out. In the analysis, emphasis was placed on the length of the domain wall as one of the most important parameters. The difference in the dynamic properties of the spiral and elliptical domain walls has been demonstrated.This research was funded by the Spanish MCIU, under PGC2018-099530-B-C31 (MCIU/AEI/FEDER, UE), by the EU under the “INFINITE”(Horizon 2020) project, by the Government of the Basque Country, under the PUE_2021_1_0009 and Elkartek (MINERVA, ZE-KONP and COMPONENS) projects, by the University of the Basque Country, under the scheme of “Ayuda a Grupos Consolidados” (Ref.: GIU18/192) and under the COLAB20/15 project and by the Diputación Foral de Gipuzkoa in the frame of Programa “Red guipuzcoana de Ciencia, Tecnología e Innovación 2021” under the 2021-CIEN-000007-01 project

Determination of Magnetic Structures in Magnetic Microwires with Longitudinally Distributed Magnetic Anisotropy

We studied the magnetic properties of a glass-covered amorphous microwire that was stress-annealed at temperatures distributed along the microwire length. The Sixtus-Tonks, Kerr effect microscopy and magnetic impedance techniques have been applied. There was a transformation of the magnetic structure across the zones subjected to annealing at different temperatures. The annealing temperature distribution induces the graded magnetic anisotropy in the studied sample. The variety of the surface domain structures depending on the longitudinal location has been discovered. Spiral, circular, curved, elliptic and longitudinal domain structures coexist and replace each other in the process of magnetization reversal. The analysis of the obtained results was carried out based on the calculations of the magnetic structure, assuming the distribution of internal stresses.This work was supported by EU under “INFINITE” (HORIZON-CL5-2021-D5-01-06) project, by the Spanish MICIN, under PID2022-141373NB-I00 project and by the Government of the Basque Country under PUE_2021_1_0009 and Elkartek (MINERVA, ZE-KONP AND COMPONENS) projects under the scheme of “Ayuda a Grupos Consolidados”(ref. IT1670-22)

Reversible and Non-Reversible Transformation of Magnetic Structure in Amorphous Microwires

We provide an overview of the tools directed to reversible and irreversible transformations of the magnetic structure of glass-covered microwires. The irreversible tools are the selection of the chemical composition, geometric ratio, and the stress-annealing. For reversible tuning we use the combination of magnetic fields and mechanical stresses. The studies were focused on the giant magnetoimpedance effect and the velocity of the domain walls propagation important for the technological applications. The essential increase of the giant magnetoimpedance effect and the control of the domain wall velocity were achieved as a result of the use of two types of control tools. The performed simulations reflect the real transformation of the helical domain structures experimentally found.This research was funded by National Science Centre Poland under Grant No. DEC-2016/22/M/ST3/00471, Spanish MCIU under PGC2018-099530-BC31 (MCIU/AEI/FEDER, UE), the Government of the Basque Country under PIBA 2018-44 projects. The authors thank for technical and human support provided by SGIker of UPV/EHU and European funding (ERDF and ESF). The research of P.G. was supported in part by PL-Grid Infrastructure

The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression.

Molecular classification of cancers into subtypes has resulted in an advance in our understanding of tumour biology and treatment response across multiple tumour types. However, to date, cancer profiling has largely focused on protein-coding genes, which comprise <1% of the genome. Here we leverage a compendium of 58,648 long noncoding RNAs (lncRNAs) to subtype 947 breast cancer samples. We show that lncRNA-based profiling categorizes breast tumours by their known molecular subtypes in breast cancer. We identify a cohort of breast cancer-associated and oestrogen-regulated lncRNAs, and investigate the role of the top prioritized oestrogen receptor (ER)-regulated lncRNA, DSCAM-AS1. We demonstrate that DSCAM-AS1 mediates tumour progression and tamoxifen resistance and identify hnRNPL as an interacting protein involved in the mechanism of DSCAM-AS1 action. By highlighting the role of DSCAM-AS1 in breast cancer biology and treatment resistance, this study provides insight into the potential clinical implications of lncRNAs in breast cancer

Personality traits and mental disorders

Peer reviewe

Art as Critique under Neoliberalism: Negativity Undoing Economic Naturalism

This essay considers the possibilities of contemporary art as a viable medium of socio-political critique within a cultural terrain dominated by naturalised neoliberal economics. It begins by considering the centrality of negativity to the historical project of critical theory most forcefully pursued by Adorno as ‘negative dialectics.’ Subsequent varieties of postmodern critique fairly dispensed with dialectics variously favouring complexity and an overriding emphasis on textuality. With the birth of neoliberalism and its burgeoning emphasis on ‘the contemporary’, economic values begin to penetrate every aspect of contemporary life and experience, including art and culture. Contemporary capitalism dematerialised as financialisation now comprises a naturalised ambience that is both everywhere and nowhere. Capitalist ambience is echoed in contemporary art that suggests criticality and yet seems to side with the imagery, values and logics of the prevailing financial order. The naturalisation of the neoliberal order is further internalised by artists online. Exacerbated contemporary emphasis on the ‘self as entrepreneur’ coincides with the biopolitical transformation of the contemporary artist into an individual ‘enterprise unit’. This is particularly observable online on social media where an artist’s whole life is simultaneously the subject and object of art. Criticality in art does not disappear but becomes ‘self-annulling’: it acts as a conduit questioning the commodity-identity of art while pointing to phenomena and affects outside the art world. With the recent appearance of the COVID-19 virus, added to the unignorable impact of global climate change, ‘real nature’ assumes a critical role, undermining neoliberalism’s ideological naturalisation while laying-bare the extent of its structural contradictions. Art criticality is revivified by divesting from art contexts saturated with neoliberal imperatives. Criticality is negatively practiced as an ‘un-’ or ‘not-doing’, defining modes of exodus while, crucially, not abandoning art’s institutional definition altogether

GOAL : A software tool for assessing biological significance of genes groups

Background: Modern high throughput experimental techniques such as DNA microarrays often result in large lists of genes. Computational biology tools such as clustering are then used to group together genes based on their similarity in expression profiles. Genes in each group are probably functionally related. The functional relevance among the genes in each group is usually characterized by utilizing available biological knowledge in public databases such as Gene Ontology (GO), KEGG pathways, association between a transcription factor (TF) and its target genes, and/or gene networks. Results: We developed GOAL: Gene Ontology AnaLyzer, a software tool specifically designed for the functional evaluation of gene groups. GOAL implements and supports efficient and statistically rigorous functional interpretations of gene groups through its integration with available GO, TF-gene association data, and association with KEGG pathways. In order to facilitate more specific functional characterization of a gene group, we implement three GO-tree search strategies rather than one as in most existing GO analysis tools. Furthermore, GOAL offers flexibility in deployment. It can be used as a standalone tool, a plug-in to other computational biology tools, or a web server application. Conclusion: We developed a functional evaluation software tool, GOAL, to perform functional characterization of a gene group. GOAL offers three GO-tree search strategies and combines its strength in function integration, portability and visualization, and its flexibility in deployment. Furthermore, GOAL can be used to evaluate and compare gene groups as the output from computational biology tools such as clustering algorithms.Des techniques exp\ue9rimentales modernes \ue0 haut d\ue9bit comme les puces \ue0 ADN donnent souvent lieu \ue0 de longues listes de g\ue8nes. On a alors recours \ue0 des outils bio-informatiques comme le regroupement (clustering) pour classer les g\ue8nes en fonction de leur similitude dans leur profil d\u2019expression. Les g\ue8nes de chaque groupe sont probablement li\ue9s de mani\ue8re fonctionnelle. La caract\ue9risation de la pertinence fonctionnelle parmi les g\ue8nes de chaque groupe s\u2019effectue habituellement en utilisant soit les connaissances biologiques accessibles dans des bases de donn\ue9es publiques comme la Gene Ontology (GO), soit la KEGG PATHWAY, soit l\u2019association entre un facteur de transcription et ses g\ue8nes cibles, ou les r\ue9seaux de g\ue8nes.Peer reviewed: YesNRC publication: Ye